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Childhood leukaemia relapse may be caused by circular DNA by-products, new discovery reveals

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August 6, 2025
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University of Leeds research published in Nature today reveals a previously overlooked type of circular DNA that may contribute to childhood leukemia relapse. The study, led by Dr. Joan Boyes from the Faculty of Biological Sciences, builds upon previous research linking leukemia to excised signal circles (ESCs) – circular forms of DNA that are typically produced as a by-product when the body…

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